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Assay Detail

CHEMBL670207

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against Dopamine receptor D2 in bovine striatal homogenate using 200 pM [3H]- spiperone and 250 nM unlabeled ketanserin
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL3998)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

N-(1-arylpropionyl)-4-aryltetrahydropyridines, a new class of high-affinity selective sigma receptor ligands.
Schuster DI, Pan YP, Singh G, Stoupakis G, Cai B, Lem G, Ehrlich GK, Frietze W, Murphy RB.
J Med Chem (1993) 36 : 3923 -3928
PubMed 7902869 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.47 6.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL325238 1 6.47
CHEMBL101664 1 -
CHEMBL446358 1 -
CHEMBL6224 1 -
CHEMBL126086 1 -
CHEMBL338181 1 -
CHEMBL126437 1 -
CHEMBL130526 1 -
CHEMBL340401 1 -
CHEMBL129521 1 -
CHEMBL125913 1 -
CHEMBL340532 1 -
CHEMBL127067 1 -
CHEMBL420344 1 -
CHEMBL130357 1 -
CHEMBL126738 1 -
CHEMBL129452 1 -
CHEMBL435211 1 -
CHEMBL340541 1 -
CHEMBL50115 1 -
CHEMBL126684 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL325238 IC50 = 335.0 nM 6.47
CHEMBL101664 IC50 > 5000.0 nM -
CHEMBL446358 IC50 > 5000.0 nM -
CHEMBL6224 IC50 > 5000.0 nM -
CHEMBL126086 IC50 > 5000.0 nM -
CHEMBL338181 IC50 > 5000.0 nM -
CHEMBL126437 IC50 > 10000.0 nM -
CHEMBL130526 IC50 > 5000.0 nM -
CHEMBL340401 IC50 > 5000.0 nM -
CHEMBL129521 IC50 > 5000.0 nM -
CHEMBL125913 IC50 > 15000.0 nM -
CHEMBL340532 IC50 > 5000.0 nM -
CHEMBL127067 IC50 > 5000.0 nM -
CHEMBL420344 IC50 > 5000.0 nM -
CHEMBL130357 IC50 > 5000.0 nM -
CHEMBL126738 IC50 > 5000.0 nM -
CHEMBL129452 IC50 > 5000.0 nM -
CHEMBL435211 IC50 > 5000.0 nM -
CHEMBL340541 IC50 > 5000.0 nM -
CHEMBL50115 IC50 > 5000.0 nM -
CHEMBL126684 IC50 > 13000.0 nM -