Assay Detail
Binding
CHEMBL670208
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Binding affinity against D2 receptor in calf caudate nucleus
44
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 6.90 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299561 | — | — | 1 | 8.52 |
| CHEMBL50993 | — | — | 1 | 8.40 |
| CHEMBL298534 | — | — | 1 | 8.15 |
| CHEMBL27763 | — | — | 1 | 8.10 |
| CHEMBL50530 | — | — | 3 | 8.00 |
| CHEMBL48925 | — | — | 1 | 8.00 |
| CHEMBL301060 | — | — | 3 | 8.00 |
| CHEMBL50722 | — | — | 1 | 7.70 |
| CHEMBL416747 | — | — | 1 | 7.70 |
| CHEMBL52396 | — | — | 1 | 7.52 |
| CHEMBL54266 | — | — | 1 | 7.52 |
| CHEMBL284912 | — | — | 1 | 7.52 |
| CHEMBL52485 | — | — | 1 | 7.40 |
| CHEMBL283606 | — | — | 3 | 7.30 |
| CHEMBL51888 | — | — | 3 | 7.30 |
| CHEMBL25984 | — | — | 1 | 7.22 |
| CHEMBL300735 | — | — | 3 | 7.22 |
| CHEMBL54089 | — | — | 1 | 7.10 |
| CHEMBL51561 | — | — | 1 | 7.05 |
| CHEMBL52438 | — | — | 1 | 7.00 |
| CHEMBL553833 | — | — | 1 | 7.00 |
| CHEMBL27995 | — | — | 1 | 6.40 |
| CHEMBL264027 | — | — | 1 | 6.22 |
| CHEMBL50188 | — | — | 1 | 6.22 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 6.10 |
| CHEMBL52785 | — | — | 1 | 6.05 |
| CHEMBL51985 | — | — | 1 | 6.00 |
| CHEMBL285010 | — | — | 1 | 5.60 |
| CHEMBL50841 | — | — | 1 | 5.52 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299561 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL50993 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL298534 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL27763 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL301060 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL50530 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL301060 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL48925 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL50722 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL416747 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL50530 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL54266 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL284912 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL52396 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL52485 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL283606 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL51888 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL300735 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL25984 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL54089 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL51561 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL52438 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL553833 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL50530 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL300735 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL51888 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL283606 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL300735 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL283606 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL27995 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL51888 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL264027 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL50188 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL52785 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL51985 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL285010 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL50841 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL301060 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL296395 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL545198 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL417550 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL8412 | IPSAPIRONE | IC50 | > | 1000000.0 | nM | - |