Assay Detail
Binding
CHEMBL670209
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Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]raclopride
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.55 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64878 | — | — | 1 | 9.11 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.92 |
| CHEMBL304438 | — | — | 1 | 8.52 |
| CHEMBL59823 | — | — | 1 | 8.28 |
| CHEMBL292935 | — | — | 1 | 8.22 |
| CHEMBL294730 | — | — | 1 | 8.15 |
| CHEMBL64610 | — | — | 1 | 8.10 |
| CHEMBL60885 | — | — | 1 | 8.00 |
| CHEMBL61819 | — | — | 1 | 8.00 |
| CHEMBL61869 | — | — | 1 | 7.57 |
| CHEMBL293923 | — | — | 1 | 7.40 |
| CHEMBL61818 | — | — | 1 | 7.30 |
| CHEMBL64845 | — | — | 1 | 7.24 |
| CHEMBL59741 | — | — | 1 | 7.22 |
| CHEMBL60447 | — | — | 1 | 7.15 |
| CHEMBL59637 | — | — | 1 | 7.00 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.85 |
| CHEMBL60047 | — | — | 1 | 6.82 |
| CHEMBL418499 | — | — | 1 | 6.70 |
| CHEMBL64167 | — | — | 1 | 6.00 |
| CHEMBL60318 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64878 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL304438 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL59823 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL292935 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL294730 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL64610 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL60885 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL61819 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL61869 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL293923 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL61818 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL64845 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL59741 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL60447 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL59637 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL60047 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL418499 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL64167 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL60318 | — | IC50 | = | 1000.0 | nM | 6.00 |