Assay Detail
Binding
CHEMBL670280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
R and S enantiomers of 11-hydroxy- and 10,11-dihydroxy-N-allylnoraporphine: synthesis and affinity for dopamine receptors in rat brain tissue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.10 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 6.47 |
| CHEMBL1788212 | — | — | 1 | 6.34 |
| CHEMBL330274 | — | — | 1 | 5.87 |
| CHEMBL319557 | — | — | 1 | 5.71 |
| CHEMBL1744043 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL1788212 | — | Ki | = | 452.0 | nM | 6.34 |
| CHEMBL330274 | — | Ki | = | 1345.0 | nM | 5.87 |
| CHEMBL319557 | — | Ki | = | 1973.0 | nM | 5.71 |
| CHEMBL1744043 | — | Ki | > | 10000.0 | nM | - |