Assay Detail
Binding
CHEMBL670434
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Binding affinity for dopamine receptor D1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.27 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.05 |
| CHEMBL86931 | — | — | 1 | 8.52 |
| CHEMBL543390 | — | — | 1 | 8.29 |
| CHEMBL100572 | — | — | 1 | 8.27 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 7.19 |
| CHEMBL542436 | — | — | 1 | 7.06 |
| CHEMBL541838 | — | — | 1 | 6.99 |
| CHEMBL555619 | — | — | 1 | 6.78 |
| CHEMBL544099 | — | — | 1 | 6.58 |
| CHEMBL545264 | — | — | 1 | 6.55 |
| CHEMBL538520 | — | — | 1 | 6.44 |
| CHEMBL543389 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL86931 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL543390 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL100572 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL24077 | (R)-SKF-38393 | Ki | = | 64.1 | nM | 7.19 |
| CHEMBL542436 | — | Ki | = | 86.4 | nM | 7.06 |
| CHEMBL541838 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL555619 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL544099 | — | Ki | = | 263.0 | nM | 6.58 |
| CHEMBL545264 | — | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL538520 | — | Ki | = | 366.0 | nM | 6.44 |
| CHEMBL543389 | — | Ki | = | 2820.0 | nM | 5.55 |