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Assay Detail

CHEMBL670435

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(1A) dopamine receptor (CHEMBL265)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.
Hedberg MH, Linnanen T, Jansen JM, Nordvall G, Hjorth S, Unelius L, Johansson AM.
J Med Chem (1996) 39 : 3503 -3513
PubMed 8784448 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 6.43 7.69

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL119455 1 7.69
CHEMBL53 APOMORPHINE 4.0 1 6.63
CHEMBL118254 1 6.57
CHEMBL115969 1 6.55
CHEMBL333836 1 6.41
CHEMBL117841 1 6.22
CHEMBL27940 1 6.16
CHEMBL281357 1 6.14
CHEMBL27559 1 5.96
CHEMBL332332 1 5.96
CHEMBL119401 1 -
CHEMBL119384 1 -
CHEMBL119132 1 -
CHEMBL333085 1 -
CHEMBL119154 1 -
CHEMBL333725 1 -
CHEMBL324073 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL119455 Ki = 20.4 nM 7.69
CHEMBL53 APOMORPHINE Ki = 236.0 nM 6.63
CHEMBL118254 Ki = 270.0 nM 6.57
CHEMBL115969 Ki = 279.0 nM 6.55
CHEMBL333836 Ki = 386.0 nM 6.41
CHEMBL117841 Ki = 606.0 nM 6.22
CHEMBL27940 Ki = 700.0 nM 6.16
CHEMBL281357 Ki = 717.0 nM 6.14
CHEMBL27559 Ki = 1090.0 nM 5.96
CHEMBL332332 Ki = 1097.0 nM 5.96
CHEMBL119401 Ki > 10000.0 nM -
CHEMBL119384 Ki > 3000.0 nM -
CHEMBL119132 Ki > 5000.0 nM -
CHEMBL333085 Ki > 3000.0 nM -
CHEMBL119154 Ki > 5000.0 nM -
CHEMBL333725 Ki > 10000.0 nM -
CHEMBL324073 Ki > 4000.0 nM -