Assay Detail
Binding
CHEMBL670438
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.47 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303313 | — | — | 1 | 8.72 |
| CHEMBL64875 | — | — | 1 | 8.70 |
| CHEMBL64249 | CLOROTEPINE | 2.0 | 1 | 8.64 |
| CHEMBL121274 | — | — | 1 | 7.85 |
| CHEMBL333955 | — | — | 1 | 7.85 |
| CHEMBL368324 | — | — | 1 | 7.79 |
| CHEMBL118889 | — | — | 1 | 7.74 |
| CHEMBL116542 | — | — | 1 | 7.70 |
| CHEMBL2111781 | — | — | 1 | 7.66 |
| CHEMBL119687 | — | — | 1 | 7.57 |
| CHEMBL120512 | — | — | 1 | 7.57 |
| CHEMBL333455 | — | — | 1 | 7.51 |
| CHEMBL332600 | — | — | 1 | 7.29 |
| CHEMBL118092 | — | — | 1 | 7.28 |
| CHEMBL2111783 | — | — | 2 | 7.22 |
| CHEMBL118919 | — | — | 1 | 7.14 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.07 |
| CHEMBL2111782 | — | — | 2 | 6.86 |
| CHEMBL333246 | — | — | 1 | 6.67 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.50 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303313 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL64875 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL64249 | CLOROTEPINE | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL121274 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL333955 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL368324 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL118889 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL116542 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2111781 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL119687 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL120512 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL333455 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL332600 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL118092 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL2111783 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL2111783 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL118919 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL715 | OLANZAPINE | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL2111782 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL2111782 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL333246 | — | Ki | = | 216.0 | nM | 6.67 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 318.0 | nM | 6.50 |
| CHEMBL42 | CLOZAPINE | Ki | = | 350.0 | nM | 6.46 |