Assay Detail
Binding
CHEMBL670442
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In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.20 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304902 | CLOTHIAPINE | 2.0 | 1 | 7.85 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.55 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.46 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.12 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.94 |
| CHEMBL63756 | FLUPERLAPINE | 2.0 | 1 | 6.85 |
| CHEMBL304493 | — | — | 1 | 6.67 |
| CHEMBL67284 | ISOCLOTHIAPINE | — | 1 | 6.62 |
| CHEMBL67298 | — | — | 1 | 6.52 |
| CHEMBL63329 | — | — | 1 | 6.40 |
| CHEMBL63347 | — | — | 1 | 6.17 |
| CHEMBL67355 | — | — | 1 | 6.14 |
| CHEMBL63590 | — | — | 1 | 5.95 |
| CHEMBL63576 | — | — | 1 | 5.67 |
| CHEMBL303173 | — | — | 1 | 5.62 |
| CHEMBL65768 | — | — | 1 | 5.52 |
| CHEMBL63390 | — | — | 1 | 5.22 |
| CHEMBL66730 | — | — | 1 | 4.87 |
| CHEMBL292738 | — | — | 1 | 4.52 |
| CHEMBL303435 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304902 | CLOTHIAPINE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL415300 | ISOCLOZAPINE | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL42 | CLOZAPINE | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL63756 | FLUPERLAPINE | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL304493 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL67284 | ISOCLOTHIAPINE | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL67298 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL63329 | — | Ki | = | 398.0 | nM | 6.40 |
| CHEMBL63347 | — | Ki | = | 677.0 | nM | 6.17 |
| CHEMBL67355 | — | Ki | = | 726.0 | nM | 6.14 |
| CHEMBL63590 | — | Ki | = | 1135.0 | nM | 5.95 |
| CHEMBL63576 | — | Ki | = | 2140.0 | nM | 5.67 |
| CHEMBL303173 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL65768 | — | Ki | = | 3020.0 | nM | 5.52 |
| CHEMBL63390 | — | Ki | = | 6020.0 | nM | 5.22 |
| CHEMBL66730 | — | Ki | = | 13500.0 | nM | 4.87 |
| CHEMBL292738 | — | Ki | = | 30200.0 | nM | 4.52 |
| CHEMBL303435 | — | Ki | = | 47900.0 | nM | 4.32 |