Assay Detail
Binding
CHEMBL670558
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Binding Affinity on High Affinity Site of Dopamine receptor D2S
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.87 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.77 |
| CHEMBL162762 | — | — | 1 | 6.60 |
| CHEMBL163087 | — | — | 1 | 6.01 |
| CHEMBL165171 | — | — | 1 | 5.14 |
| CHEMBL164736 | — | — | 1 | 4.89 |
| CHEMBL164950 | — | — | 1 | 4.82 |
| CHEMBL350161 | — | — | 1 | - |
| CHEMBL164631 | — | — | 1 | - |
| CHEMBL165022 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL162762 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL163087 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL165171 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL164736 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL164950 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL350161 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL164631 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL165022 | — | Ki | > | 20000.0 | nM | - |