Compound Detail
CHEMBL164736
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Basic Information
| ChEMBL ID | CHEMBL164736 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UKMLUIQURILEME-UHFFFAOYSA-N |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
387.8
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 5.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL219 | Ki | 5.72 | 5.72 | 1900.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 5.55 | 5.55 | 2800.0 | 1 |
| D(1A) dopamine receptor CHEMBL2967 | Ki | 5.41 | 5.41 | 3900.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 4.96 | 4.925 | 11000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(4) dopamine receptor | Ki | = | 1900.0 | nM | 5.72 | Binding Affinity was tested on the high affinity site of Dopamine receptor D4.4 | 10691700 |
| D(3) dopamine receptor | Ki | = | 2800.0 | nM | 5.55 | Binding Affinity was tested on the high affinity site of Dopamine receptor D3 | 10691700 |
| D(1A) dopamine receptor | Ki | = | 3900.0 | nM | 5.41 | Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor... | 10691700 |
| D(2) dopamine receptor | Ki | = | 11000.0 | nM | 4.96 | Binding affinity on High Affinity Site of Dopamine receptor D2L | 10691700 |
| D(2) dopamine receptor | Ki | = | 13000.0 | nM | 4.89 | Binding Affinity on High Affinity Site of Dopamine receptor D2S | 10691700 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10691700 | 10.1021/jm991098z | D(2) dopamine receptor | 2 |
| 10691700 | 10.1021/jm991098z | D(3) dopamine receptor | 1 |
| 10691700 | 10.1021/jm991098z | D(4) dopamine receptor | 1 |
| 10691700 | 10.1021/jm991098z | D(1A) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine