Assay Detail
Binding
CHEMBL670585
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Compound was tested for binding against Dopamine transporter using radioligand as [3H]-RTI 55
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.08 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102119 | — | — | 1 | 8.96 |
| CHEMBL143612 | — | — | 1 | 8.80 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102119 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL143612 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL370805 | COCAINE | IC50 | = | 341.0 | nM | 6.47 |