Assay Detail
Functional
CHEMBL670592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]dopamine uptake at the dopamine transporter in rat striatal tissue
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.88 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337510 | — | — | 1 | 9.59 |
| CHEMBL133786 | — | — | 1 | 8.89 |
| CHEMBL129899 | — | — | 1 | 8.85 |
| CHEMBL130477 | — | — | 1 | 8.85 |
| CHEMBL130394 | — | — | 1 | 8.77 |
| CHEMBL133795 | — | — | 1 | 8.51 |
| CHEMBL130255 | — | — | 1 | 8.47 |
| CHEMBL781 | MAZINDOL | 4.0 | 1 | 8.08 |
| CHEMBL336654 | — | — | 1 | 8.07 |
| CHEMBL132198 | — | — | 1 | 8.07 |
| CHEMBL132241 | — | — | 1 | 8.04 |
| CHEMBL129885 | — | — | 1 | 7.96 |
| CHEMBL335296 | — | — | 1 | 7.85 |
| CHEMBL336413 | — | — | 1 | 7.82 |
| CHEMBL337052 | — | — | 1 | 7.75 |
| CHEMBL133355 | — | — | 1 | 7.59 |
| CHEMBL339169 | — | — | 1 | 7.28 |
| CHEMBL336313 | — | — | 1 | 7.26 |
| CHEMBL442765 | — | — | 1 | 7.24 |
| CHEMBL147748 | — | — | 1 | 7.11 |
| CHEMBL132206 | — | — | 1 | 7.05 |
| CHEMBL130198 | — | — | 1 | 7.04 |
| CHEMBL133902 | — | — | 1 | 6.91 |
| CHEMBL339841 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337510 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL133786 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL129899 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL130477 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL130394 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL133795 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL130255 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL781 | MAZINDOL | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL336654 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL132198 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL132241 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL129885 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL335296 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL336413 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL337052 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL133355 | — | IC50 | = | 25.4 | nM | 7.59 |
| CHEMBL339169 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL336313 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL442765 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL147748 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL132206 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL130198 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL133902 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL339841 | — | IC50 | = | 770.0 | nM | 6.11 |