Assay Detail
Binding
CHEMBL670595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its ability to inhibit the neurotransmitter dopamine-DA reuptake system using [3H]dopamine as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and evaluation of novel-N-[2-(bis-aryl-methoxy)ethyl-N-aralkyl-,-alkanediamines as potent and selective dopamine reuptake inhibitors: Seco analogs of GBR12935 and GBR12909
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.92 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 8.37 |
| CHEMBL83296 | — | — | 1 | 8.00 |
| CHEMBL26320 | — | — | 1 | 7.43 |
| CHEMBL313068 | — | — | 1 | 7.31 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.05 |
| CHEMBL86260 | — | — | 1 | 6.82 |
| CHEMBL87360 | — | — | 1 | 6.30 |
| CHEMBL84584 | — | — | 1 | 6.11 |
| CHEMBL1698 | BUPROPION HYDROCHLORIDE | 4.0 | 1 | 5.91 |
| CHEMBL314666 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL83296 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL26320 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL313068 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL370805 | COCAINE | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL86260 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL87360 | — | IC50 | = | 505.0 | nM | 6.30 |
| CHEMBL84584 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1698 | BUPROPION HYDROCHLORIDE | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL314666 | — | IC50 | = | 1230.0 | nM | 5.91 |