Assay Detail
Binding
CHEMBL670597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity against cocaine binding site of dopamine transporter in rat striatum using [3H]2b as radioligand.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, ligand binding, QSAR, and CoMFA study of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.84 | 8.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610897 | — | — | 1 | 8.93 |
| CHEMBL300226 | — | — | 1 | 8.90 |
| CHEMBL2373962 | — | — | 1 | 8.77 |
| CHEMBL2310929 | — | — | 1 | 8.74 |
| CHEMBL2310852 | — | — | 1 | 8.67 |
| CHEMBL2373744 | — | — | 1 | 8.09 |
| CHEMBL1237136 | — | — | 1 | 8.00 |
| CHEMBL2373745 | — | — | 1 | 7.88 |
| CHEMBL2079586 | — | — | 1 | 7.80 |
| CHEMBL1790051 | — | — | 1 | 7.64 |
| CHEMBL607198 | — | — | 1 | 7.61 |
| CHEMBL2310855 | — | — | 1 | 7.19 |
| CHEMBL2310854 | — | — | 1 | 7.17 |
| CHEMBL120901 | — | — | 1 | 6.99 |
| CHEMBL2310851 | — | — | 1 | 6.59 |
| CHEMBL2310853 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610897 | — | IC50 | = | 1.17 | nM | 8.93 |
| CHEMBL300226 | — | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL2373962 | — | IC50 | = | 1.71 | nM | 8.77 |
| CHEMBL2310929 | — | IC50 | = | 1.81 | nM | 8.74 |
| CHEMBL2310852 | — | IC50 | = | 2.12 | nM | 8.67 |
| CHEMBL2373744 | — | IC50 | = | 8.14 | nM | 8.09 |
| CHEMBL1237136 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL2373745 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL2079586 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL1790051 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL607198 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL2310855 | — | IC50 | = | 64.2 | nM | 7.19 |
| CHEMBL2310854 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL120901 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2310851 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL2310853 | — | IC50 | = | 316.0 | nM | 6.50 |