Assay Detail
Binding
CHEMBL670611
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Ability to inhibit the binding of [3H]spiroperidol in rat striatal tissue
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and neuroleptic activity of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.88 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164940 | — | — | 1 | 8.17 |
| CHEMBL350575 | — | — | 1 | 7.92 |
| CHEMBL168104 | — | — | 1 | 7.89 |
| CHEMBL351954 | — | — | 1 | 7.70 |
| CHEMBL165301 | — | — | 1 | 7.60 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.39 |
| CHEMBL165775 | — | — | 1 | 7.38 |
| CHEMBL166095 | — | — | 1 | 7.33 |
| CHEMBL165857 | — | — | 1 | 7.17 |
| CHEMBL166311 | — | — | 1 | 7.16 |
| CHEMBL349840 | — | — | 1 | 7.16 |
| CHEMBL344115 | — | — | 1 | 7.11 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.11 |
| CHEMBL165576 | — | — | 1 | 7.06 |
| CHEMBL349632 | — | — | 1 | 6.85 |
| CHEMBL164973 | — | — | 1 | 6.85 |
| CHEMBL351707 | — | — | 1 | 6.82 |
| CHEMBL163680 | — | — | 1 | 6.82 |
| CHEMBL166298 | — | — | 1 | 6.72 |
| CHEMBL164679 | — | — | 1 | 6.70 |
| CHEMBL163832 | — | — | 1 | 6.57 |
| CHEMBL165133 | — | — | 1 | 6.47 |
| CHEMBL350957 | — | — | 1 | 6.38 |
| CHEMBL354250 | — | — | 1 | 6.38 |
| CHEMBL165797 | — | — | 1 | 6.24 |
| CHEMBL167086 | — | — | 1 | 5.96 |
| CHEMBL165077 | — | — | 1 | 5.55 |
| CHEMBL163656 | — | — | 1 | 5.55 |
| CHEMBL164584 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164940 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL350575 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL168104 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL351954 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL165301 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL165775 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL166095 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL165857 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL166311 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL349840 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL344115 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL165576 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL349632 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL164973 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL351707 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL163680 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL166298 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL164679 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL163832 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL165133 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL350957 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL354250 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL165797 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL167086 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL165077 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL163656 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL164584 | — | IC50 | = | 3800.0 | nM | 5.42 |