Assay Detail
Functional
CHEMBL670916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo antagonist dissociation constant in intaraurethral pressure model in dogs.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.64 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | 4.0 | 1 | 8.87 |
| CHEMBL445325 | — | — | 1 | 8.30 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 7.12 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 7.02 |
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | Kd | = | 1.349 | nM | 8.87 |
| CHEMBL445325 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL707 | DOXAZOSIN | Kd | = | 75.86 | nM | 7.12 |
| CHEMBL611 | TERAZOSIN | Kd | = | 95.5 | nM | 7.02 |
| CHEMBL709 | ALFUZOSIN | Kd | = | 134.9 | nM | 6.87 |