Assay Detail
Functional
CHEMBL670917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Intraurethral pressure (IUP) in Beagle dogs values are expressed as pseudo pA2 values.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Tissue | Urethra |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.82 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291262 | — | — | 1 | 8.25 |
| CHEMBL40650 | — | — | 1 | 8.17 |
| CHEMBL2112073 | — | — | 1 | 7.73 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291262 | — | Kd | = | 5.623 | nM | 8.25 |
| CHEMBL40650 | — | Kd | = | 6.761 | nM | 8.17 |
| CHEMBL2112073 | — | Kd | = | 18.62 | nM | 7.73 |
| CHEMBL707 | DOXAZOSIN | Kd | = | 75.86 | nM | 7.12 |