Assay Detail
Binding
CHEMBL670960
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Inhibitory constant of compound in presence of Gpp(NH)p calculated for the low affinity components of the [3H]spiroperidol binding to Dopamine receptor D2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and dopamine receptor modulating activity of diketopiperazine peptidomimetics of L-prolyl-L-leucylglycinamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.01 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123813 | — | — | 1 | 7.30 |
| CHEMBL317488 | — | — | 1 | 7.22 |
| CHEMBL332740 | — | — | 1 | 6.76 |
| CHEMBL607228 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123813 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL317488 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL332740 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL607228 | — | Ki | = | 183.0 | nM | 6.74 |