Assay Detail
Binding
CHEMBL671031
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In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca nemestrina |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N-fluoroalkylated and N-alkylated analogues of the dopaminergic D-2 receptor antagonist raclopride.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.89 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.06 |
| CHEMBL80127 | — | — | 1 | 7.76 |
| CHEMBL418922 | — | — | 1 | 7.39 |
| CHEMBL80126 | — | — | 1 | 7.05 |
| CHEMBL81778 | — | — | 1 | 6.89 |
| CHEMBL312602 | — | — | 1 | 6.80 |
| CHEMBL77448 | — | — | 1 | 5.58 |
| CHEMBL2021339 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8809 | RACLOPRIDE | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL80127 | — | Ki | = | 17.3 | nM | 7.76 |
| CHEMBL418922 | — | Ki | = | 41.1 | nM | 7.39 |
| CHEMBL80126 | — | Ki | = | 88.5 | nM | 7.05 |
| CHEMBL81778 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL312602 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL77448 | — | Ki | = | 2610.0 | nM | 5.58 |
| CHEMBL2021339 | — | Ki | = | 2620.0 | nM | 5.58 |