Assay Detail

CHEMBL671224

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Binding

Inhibitory activity against bovine adrenal dopamine beta-hydroxylase (DBH)

ChEMBL ↗

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Target

Dopamine beta-hydroxylase (CHEMBL4702) ↗

Open DB target context

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Dopamine beta-hydroxylase (CHEMBL4702) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Dopamine beta-hydroxylase

CHEMBL4702

Anchored from Assay target.

Protein identity Dopamine beta-hydroxylase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Dopamine beta-hydroxylase (CHEMBL4702) ↗

Type	SINGLE PROTEIN
Organism	Bos taurus

Publication

1-(Thienylalkyl)imidazole-2(3H)-thiones as potent competitive inhibitors of dopamine beta-hydroxylase.

McCarthy JR, Matthews DP, Broersma RJ, McDermott RD, Kastner PR, Hornsperger JM, Demeter DA, Weintraub HJ, Whitten JP.
J Med Chem (1990) 33 : 1866 -1873
PubMed 2362264 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.68	6.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL278068	—	—	1	6.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL278068	—	IC50	=	210.0	nM	6.68