Assay Detail
Binding
CHEMBL671225
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Inhibitory activity was determined against bovine dopamine beta-hydroxylase (DBH)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine beta-hydroxylase. 4. Structure-activity relationships at the copper binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.34 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351873 | — | — | 1 | 7.46 |
| CHEMBL433493 | — | — | 1 | 7.13 |
| CHEMBL165242 | — | — | 1 | 6.18 |
| CHEMBL165150 | — | — | 1 | 6.00 |
| CHEMBL278068 | — | — | 1 | 5.92 |
| CHEMBL352449 | — | — | 1 | 5.85 |
| CHEMBL165032 | — | — | 1 | 5.81 |
| CHEMBL165206 | — | — | 1 | 5.72 |
| CHEMBL350128 | — | — | 1 | 5.66 |
| CHEMBL164747 | — | — | 1 | 5.58 |
| CHEMBL351468 | — | — | 1 | 5.55 |
| CHEMBL351936 | — | — | 1 | 5.43 |
| CHEMBL63907 | — | — | 1 | 5.25 |
| CHEMBL165154 | — | — | 1 | 5.21 |
| CHEMBL350557 | — | — | 1 | 5.21 |
| CHEMBL348820 | — | — | 1 | 4.87 |
| CHEMBL352685 | — | — | 1 | 4.82 |
| CHEMBL349152 | — | — | 1 | 4.80 |
| CHEMBL349889 | — | — | 1 | 4.62 |
| CHEMBL164791 | — | — | 1 | 4.50 |
| CHEMBL352155 | — | — | 1 | 4.24 |
| CHEMBL355612 | — | — | 1 | 4.21 |
| CHEMBL351892 | — | — | 1 | 4.12 |
| CHEMBL423819 | — | — | 1 | 4.10 |
| CHEMBL165087 | — | — | 1 | - |
| CHEMBL164646 | — | — | 1 | - |
| CHEMBL351275 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351873 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL433493 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL165242 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL165150 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL278068 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL352449 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL165032 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL165206 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL350128 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL164747 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL351468 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL351936 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL63907 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL165154 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL350557 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL348820 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL352685 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL349152 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL349889 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL164791 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL352155 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL355612 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL351892 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL423819 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL165087 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL164646 | — | IC50 | = | 240000.0 | nM | - |
| CHEMBL351275 | — | IC50 | = | 165000.0 | nM | - |