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Assay Detail

CHEMBL671327

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(1A) dopamine receptor (CHEMBL2967)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding.
Lehmann T, Hübner H, Gmeiner P.
Bioorg Med Chem Lett (2001) 11 : 2863 -2866
PubMed 11597417 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 4.37 4.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL440143 1 4.92
CHEMBL95230 1 4.89
CHEMBL316983 1 4.58
CHEMBL96958 1 4.54
CHEMBL98072 1 4.36
CHEMBL97436 1 4.33
CHEMBL97283 1 4.17
CHEMBL97750 1 4.15
CHEMBL97319 1 4.10
CHEMBL323557 1 4.08
CHEMBL95618 1 4.00
CHEMBL97348 1 -
CHEMBL98071 1 -
CHEMBL96998 1 -
CHEMBL318924 1 -
CHEMBL98563 1 -
CHEMBL99291 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL440143 Ki = 12000.0 nM 4.92
CHEMBL95230 Ki = 13000.0 nM 4.89
CHEMBL316983 Ki = 26000.0 nM 4.58
CHEMBL96958 Ki = 29000.0 nM 4.54
CHEMBL98072 Ki = 44000.0 nM 4.36
CHEMBL97436 Ki = 47000.0 nM 4.33
CHEMBL97283 Ki = 68000.0 nM 4.17
CHEMBL97750 Ki = 71000.0 nM 4.15
CHEMBL97319 Ki = 80000.0 nM 4.10
CHEMBL323557 Ki = 83000.0 nM 4.08
CHEMBL95618 Ki = 100000.0 nM 4.00
CHEMBL97348 Ki > 100000.0 nM -
CHEMBL98071 Ki > 100000.0 nM -
CHEMBL96998 Ki > 100000.0 nM -
CHEMBL318924 Ki > 100000.0 nM -
CHEMBL98563 Ki > 100000.0 nM -
CHEMBL99291 Ki > 100000.0 nM -