Assay Detail
Binding
CHEMBL671330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.04 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366388 | — | — | 1 | 6.00 |
| CHEMBL368061 | — | — | 3 | 5.69 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 5.21 |
| CHEMBL177031 | — | — | 2 | 4.71 |
| CHEMBL354210 | — | — | 1 | 4.66 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366388 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL368061 | — | Ki | = | 2060.0 | nM | 5.69 |
| CHEMBL368061 | — | Ki | = | 3090.0 | nM | 5.51 |
| CHEMBL49 | BUSPIRONE | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL368061 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL177031 | — | Ki | = | 19700.0 | nM | 4.71 |
| CHEMBL354210 | — | Ki | = | 21900.0 | nM | 4.66 |
| CHEMBL177031 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 87300.0 | nM | 4.06 |