Assay Detail
Binding
CHEMBL671375
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity to displace [3H]spiperone from cloned human Dopamine receptor D2 stably expressed in CHO cell lines
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.05 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90005 | — | — | 1 | 8.11 |
| CHEMBL93432 | — | — | 1 | 8.06 |
| CHEMBL91669 | — | — | 1 | 7.96 |
| CHEMBL328739 | — | — | 1 | 7.82 |
| CHEMBL91498 | — | — | 1 | 7.58 |
| CHEMBL89971 | — | — | 1 | 7.42 |
| CHEMBL263162 | — | — | 1 | 7.28 |
| CHEMBL91162 | — | — | 1 | 7.25 |
| CHEMBL93969 | — | — | 1 | 7.22 |
| CHEMBL94283 | — | — | 1 | 7.14 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.13 |
| CHEMBL93958 | — | — | 1 | 7.09 |
| CHEMBL316125 | — | — | 1 | 7.08 |
| CHEMBL91621 | — | — | 1 | 7.07 |
| CHEMBL92859 | — | — | 1 | 7.02 |
| CHEMBL450021 | — | — | 1 | 6.96 |
| CHEMBL328667 | — | — | 1 | 6.82 |
| CHEMBL94023 | — | — | 1 | 6.77 |
| CHEMBL91272 | — | — | 1 | 6.72 |
| CHEMBL91229 | — | — | 1 | 6.66 |
| CHEMBL91553 | — | — | 1 | 6.57 |
| CHEMBL91821 | — | — | 1 | 6.55 |
| CHEMBL92189 | — | — | 1 | 6.54 |
| CHEMBL327176 | — | — | 1 | 6.48 |
| CHEMBL91155 | — | — | 1 | 6.05 |
| CHEMBL93832 | — | — | 1 | 5.89 |
| CHEMBL93970 | — | — | 1 | - |
| CHEMBL327339 | — | — | 1 | - |
| CHEMBL431095 | — | — | 1 | - |
| CHEMBL90711 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90005 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL93432 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL91669 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL328739 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL91498 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL89971 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL263162 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL91162 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL93969 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL94283 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL42 | CLOZAPINE | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL93958 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL316125 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL91621 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL92859 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL450021 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL328667 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL94023 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL91272 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL91229 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL91553 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL91821 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL92189 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL327176 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL91155 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL93832 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL93970 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL327339 | — | Ki | > | 1600.0 | nM | - |
| CHEMBL431095 | — | Ki | > | 1900.0 | nM | - |
| CHEMBL90711 | — | Ki | > | 1600.0 | nM | - |
| CHEMBL327310 | — | Ki | > | 1700.0 | nM | - |
| CHEMBL444309 | — | Ki | > | 1700.0 | nM | - |