Compound Detail
CHEMBL91155
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Basic Information
| ChEMBL ID | CHEMBL91155 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SVAAEZGFWVDPDN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
377.5
MW (Da)
4.41
ALogP
5
HBA
1
HBD
50.5
PSA (Ų)
0.72
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL219 | Ki | 9.19 | 9.19 | 0.6 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 6.05 | 6.05 | 900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(4) dopamine receptor | Ki | = | 0.64 | nM | 9.19 | Affinity to displace [3H]spiperone from cloned human Dopamine receptor D4 stably... | 10411491 |
| D(2) dopamine receptor | Ki | = | 900.0 | nM | 6.05 | Affinity to displace [3H]spiperone from cloned human Dopamine receptor D2 stably... | 10411491 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10411491 | 10.1021/jm991029k | D(2) dopamine receptor | 1 |
| 10411491 | 10.1021/jm991029k | D(3) dopamine receptor | 1 |
| 10411491 | 10.1021/jm991029k | D(4) dopamine receptor | 1 |
| 10411491 | 10.1021/jm991029k | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine