Assay Detail
Binding
CHEMBL671695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity to displace [3H]spiperone from cloned human Dopamine receptor D4 stably expressed in HEK393 cell lines
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK393 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 8.43 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92859 | — | — | 1 | 9.48 |
| CHEMBL93832 | — | — | 1 | 9.34 |
| CHEMBL91229 | — | — | 1 | 9.25 |
| CHEMBL91162 | — | — | 1 | 9.22 |
| CHEMBL91155 | — | — | 1 | 9.19 |
| CHEMBL94023 | — | — | 1 | 9.15 |
| CHEMBL328739 | — | — | 1 | 9.12 |
| CHEMBL91669 | — | — | 1 | 9.08 |
| CHEMBL91498 | — | — | 1 | 9.07 |
| CHEMBL431095 | — | — | 1 | 9.02 |
| CHEMBL90005 | — | — | 1 | 9.00 |
| CHEMBL263162 | — | — | 1 | 8.96 |
| CHEMBL89971 | — | — | 1 | 8.96 |
| CHEMBL93969 | — | — | 1 | 8.89 |
| CHEMBL92189 | — | — | 1 | 8.77 |
| CHEMBL316125 | — | — | 1 | 8.70 |
| CHEMBL93970 | — | — | 1 | 8.68 |
| CHEMBL444309 | — | — | 1 | 8.46 |
| CHEMBL93432 | — | — | 1 | 8.35 |
| CHEMBL91553 | — | — | 1 | 8.35 |
| CHEMBL94283 | — | — | 1 | 8.28 |
| CHEMBL328667 | — | — | 1 | 8.26 |
| CHEMBL327176 | — | — | 1 | 8.26 |
| CHEMBL450021 | — | — | 1 | 7.92 |
| CHEMBL93958 | — | — | 1 | 7.75 |
| CHEMBL327310 | — | — | 1 | 7.47 |
| CHEMBL91821 | — | — | 1 | 7.15 |
| CHEMBL91272 | — | — | 1 | 6.82 |
| CHEMBL91621 | — | — | 1 | 6.41 |
| CHEMBL327339 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92859 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL93832 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL91229 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL91162 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL91155 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL94023 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL328739 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL91669 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL91498 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL431095 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL90005 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL263162 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL89971 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL93969 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL92189 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL316125 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL93970 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL444309 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL93432 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL91553 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL94283 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL328667 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL327176 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL450021 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL93958 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL327310 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL91821 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL91272 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL91621 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL327339 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL90711 | — | Ki | > | 2500.0 | nM | - |