Assay Detail
Binding
CHEMBL671629
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In vitro inhibitory activity against radioligand [3H]-WN 35,428 binding to dopamine transporter (DAT) in rat striatal tissue
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.70 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81525 | — | — | 1 | 9.21 |
| CHEMBL306208 | — | — | 1 | 8.95 |
| CHEMBL2079586 | — | — | 1 | 7.86 |
| CHEMBL1790051 | — | — | 1 | 7.64 |
| CHEMBL67387 | — | — | 1 | 7.58 |
| CHEMBL340523 | — | — | 1 | 7.30 |
| CHEMBL334546 | — | — | 1 | 7.26 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.05 |
| CHEMBL127623 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81525 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL306208 | — | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL2079586 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL1790051 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL67387 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL340523 | — | IC50 | = | 49.9 | nM | 7.30 |
| CHEMBL334546 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL370805 | COCAINE | IC50 | = | 89.1 | nM | 7.05 |
| CHEMBL127623 | — | IC50 | = | 329.0 | nM | 6.48 |