Assay Detail
Binding
CHEMBL671633
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Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.66 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131662 | — | — | 1 | 8.92 |
| CHEMBL129608 | — | — | 1 | 8.91 |
| CHEMBL442763 | — | — | 1 | 8.91 |
| CHEMBL132513 | — | — | 1 | 8.76 |
| CHEMBL127557 | — | — | 1 | 8.62 |
| CHEMBL132329 | — | — | 1 | 8.28 |
| CHEMBL336190 | — | — | 1 | 8.21 |
| CHEMBL128186 | — | — | 1 | 7.85 |
| CHEMBL335001 | — | — | 1 | 7.82 |
| CHEMBL334877 | — | — | 1 | 7.64 |
| CHEMBL340447 | — | — | 1 | 7.54 |
| CHEMBL132499 | — | — | 1 | 7.50 |
| CHEMBL130750 | — | — | 1 | 7.48 |
| CHEMBL340523 | — | — | 1 | 7.30 |
| CHEMBL334546 | — | — | 1 | 7.26 |
| CHEMBL337507 | — | — | 1 | 7.25 |
| CHEMBL129662 | — | — | 1 | 7.16 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.05 |
| CHEMBL301281 | — | — | 1 | 6.69 |
| CHEMBL131354 | — | — | 1 | 6.67 |
| CHEMBL335868 | — | — | 1 | 6.50 |
| CHEMBL337980 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131662 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL129608 | — | IC50 | = | 1.24 | nM | 8.91 |
| CHEMBL442763 | — | IC50 | = | 1.24 | nM | 8.91 |
| CHEMBL132513 | — | IC50 | = | 1.73 | nM | 8.76 |
| CHEMBL127557 | — | IC50 | = | 2.37 | nM | 8.62 |
| CHEMBL132329 | — | IC50 | = | 5.29 | nM | 8.28 |
| CHEMBL336190 | — | IC50 | = | 6.11 | nM | 8.21 |
| CHEMBL128186 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL335001 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL334877 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL340447 | — | IC50 | = | 28.6 | nM | 7.54 |
| CHEMBL132499 | — | IC50 | = | 31.6 | nM | 7.50 |
| CHEMBL130750 | — | IC50 | = | 32.8 | nM | 7.48 |
| CHEMBL340523 | — | IC50 | = | 49.9 | nM | 7.30 |
| CHEMBL334546 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL337507 | — | IC50 | = | 56.5 | nM | 7.25 |
| CHEMBL129662 | — | IC50 | = | 68.5 | nM | 7.16 |
| CHEMBL370805 | COCAINE | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL301281 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL131354 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL335868 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL337980 | — | IC50 | = | 597.0 | nM | 6.22 |