Assay Detail
Binding
CHEMBL671638
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Inhibition of [3H]WIN-35428 binding to rat striatal membrane dopamine transporter
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and ligand binding of cocaine isomers at the cocaine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.02 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370805 | COCAINE | 4.0 | 2 | 6.99 |
| CHEMBL352487 | — | — | 2 | 5.21 |
| CHEMBL170745 | — | — | 1 | 5.01 |
| CHEMBL352575 | — | — | 1 | 4.80 |
| CHEMBL171007 | — | — | 1 | 4.65 |
| CHEMBL171201 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370805 | COCAINE | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL352487 | — | IC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL170745 | — | IC50 | = | 9820.0 | nM | 5.01 |
| CHEMBL370805 | COCAINE | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL352575 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL171007 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL352487 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL171201 | — | IC50 | = | 67700.0 | nM | 4.17 |