Assay Detail
Functional
CHEMBL671687
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Tested for antagonistic activity against Endothelin B receptor in the rat cerebellum.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Cerebellum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.68 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11115 | — | — | 1 | 6.66 |
| CHEMBL274383 | PD-155080 | — | 1 | 6.30 |
| CHEMBL10733 | — | — | 1 | 6.14 |
| CHEMBL273613 | — | — | 1 | 5.35 |
| CHEMBL10374 | — | — | 1 | 5.35 |
| CHEMBL267094 | — | — | 1 | 5.28 |
| CHEMBL11131 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11115 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL274383 | PD-155080 | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL10733 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL273613 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL10374 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL267094 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL11131 | — | IC50 | = | 22000.0 | nM | 4.66 |