Assay Detail
Binding
CHEMBL671710
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Dopamine receptor binding affinity by displacing the radioligand [3H]-dopamine from dopamine receptor.
29
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships of dopaminergic 5-hydroxy-2-aminotetralin derivatives with functionalized N-alkyl substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.03 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 7.75 |
| CHEMBL171440 | — | — | 3 | 7.46 |
| CHEMBL355421 | — | — | 2 | 7.42 |
| CHEMBL170661 | — | — | 1 | 7.42 |
| CHEMBL109684 | — | — | 1 | 7.40 |
| CHEMBL170825 | — | — | 1 | 7.39 |
| CHEMBL367201 | — | — | 1 | 7.34 |
| CHEMBL173352 | — | — | 1 | 7.32 |
| CHEMBL172945 | — | — | 1 | 7.32 |
| CHEMBL273273 | 5-OH-DPAT | — | 1 | 7.31 |
| CHEMBL174184 | — | — | 1 | 7.24 |
| CHEMBL171330 | — | — | 1 | 7.17 |
| CHEMBL173913 | — | — | 1 | 7.11 |
| CHEMBL366718 | — | — | 1 | 7.04 |
| CHEMBL170018 | — | — | 1 | 7.00 |
| CHEMBL262538 | — | — | 1 | 6.96 |
| CHEMBL38992 | ETISULERGINE | 2.0 | 1 | 6.92 |
| CHEMBL174247 | — | — | 1 | 6.89 |
| CHEMBL173926 | — | — | 1 | 6.85 |
| CHEMBL422745 | — | — | 1 | 6.82 |
| CHEMBL171126 | — | — | 1 | 6.73 |
| CHEMBL171080 | — | — | 1 | 6.72 |
| CHEMBL171187 | — | — | 1 | 6.66 |
| CHEMBL174095 | DELERGOTRILE | 2.0 | 1 | 6.58 |
| CHEMBL171688 | — | — | 1 | 6.30 |
| CHEMBL171888 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL531 | PERGOLIDE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL171440 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL171440 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL355421 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL170661 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL109684 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL170825 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL355421 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL367201 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL173352 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL172945 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL273273 | 5-OH-DPAT | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL174184 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL171330 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL173913 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL366718 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL170018 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL262538 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL38992 | ETISULERGINE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL174247 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL173926 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL422745 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL171126 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL171080 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL171187 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL174095 | DELERGOTRILE | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL171440 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL171688 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL171888 | — | IC50 | = | 2000.0 | nM | 5.70 |