Compound Detail
CHEMBL355421
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL355421 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YEFAHBGREYEVJM-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
293.5
MW (Da)
3.71
ALogP
3
HBA
1
HBD
23.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.42 | 7.0225 | 38.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 38.0 | nM | 7.42 | Dopamine receptor binding affinity by displacing the radioligand [3H]-dopamine f... | 3712381 |
| Unchecked | IC50 | = | 43.0 | nM | 7.37 | Dopamine receptor binding affinity by displacing the radioligand [3H]-dopamine f... | 3712381 |
| Unchecked | IC50 | = | 220.0 | nM | 6.66 | Dopamine receptor binding affinity by displacing the radioligand [3H]spiroperido... | 3712381 |
| Unchecked | IC50 | = | 230.0 | nM | 6.64 | Dopamine receptor binding affinity by displacing the radioligand [3H]spiroperido... | 3712381 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3712381 | 10.1021/jm00156a007 | Dopamine receptor | 6 |
| 3712381 | 10.1021/jm00156a007 | Unchecked | 4 |
Data from ChEMBL 36 via Core Engine