Assay Detail
Binding
CHEMBL672928
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Dopamine receptor binding affinity by displacing the radioligand [3H]spiroperidol from dopamine receptor.
29
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships of dopaminergic 5-hydroxy-2-aminotetralin derivatives with functionalized N-alkyl substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.15 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38992 | ETISULERGINE | 2.0 | 1 | 7.60 |
| CHEMBL173352 | — | — | 1 | 6.85 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 6.84 |
| CHEMBL109684 | — | — | 1 | 6.75 |
| CHEMBL355421 | — | — | 2 | 6.66 |
| CHEMBL170825 | — | — | 1 | 6.66 |
| CHEMBL170018 | — | — | 1 | 6.43 |
| CHEMBL171440 | — | — | 3 | 6.43 |
| CHEMBL172945 | — | — | 1 | 6.40 |
| CHEMBL174095 | DELERGOTRILE | 2.0 | 1 | 6.28 |
| CHEMBL174184 | — | — | 1 | 6.28 |
| CHEMBL173913 | — | — | 1 | 6.28 |
| CHEMBL170661 | — | — | 1 | 6.08 |
| CHEMBL171330 | — | — | 1 | 6.04 |
| CHEMBL173926 | — | — | 1 | 6.04 |
| CHEMBL367201 | — | — | 1 | 5.99 |
| CHEMBL171187 | — | — | 1 | 5.89 |
| CHEMBL273273 | 5-OH-DPAT | — | 1 | 5.87 |
| CHEMBL171126 | — | — | 1 | 5.84 |
| CHEMBL366718 | — | — | 1 | 5.82 |
| CHEMBL171080 | — | — | 1 | 5.75 |
| CHEMBL262538 | — | — | 1 | 5.73 |
| CHEMBL422745 | — | — | 1 | 5.66 |
| CHEMBL171688 | — | — | 1 | 5.46 |
| CHEMBL171888 | — | — | 1 | 5.34 |
| CHEMBL174247 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38992 | ETISULERGINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL173352 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL531 | PERGOLIDE | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL109684 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL355421 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL170825 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL355421 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL170018 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL171440 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL172945 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL173913 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL174184 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL174095 | DELERGOTRILE | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL171440 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL170661 | — | IC50 | = | 825.0 | nM | 6.08 |
| CHEMBL173926 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL171330 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL367201 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL171187 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL273273 | 5-OH-DPAT | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL171126 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL366718 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL171080 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL262538 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL422745 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL171440 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL171688 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL171888 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL174247 | — | IC50 | = | 7500.0 | nM | 5.12 |