Assay Detail
Binding
CHEMBL671831
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Inhibition of dopamine beta-hydroxylase (DbetaH) enzyme
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 4.82 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433493 | — | — | 1 | 7.13 |
| CHEMBL63990 | — | — | 1 | 6.17 |
| CHEMBL278068 | — | — | 1 | 5.92 |
| CHEMBL64937 | — | — | 1 | 5.82 |
| CHEMBL67235 | — | — | 1 | 5.70 |
| CHEMBL67369 | — | — | 1 | 5.66 |
| CHEMBL293669 | — | — | 1 | 5.62 |
| CHEMBL164747 | — | — | 1 | 5.59 |
| CHEMBL63907 | — | — | 1 | 5.25 |
| CHEMBL65687 | — | — | 1 | 4.92 |
| CHEMBL65523 | — | — | 1 | 4.92 |
| CHEMBL433288 | — | — | 1 | 4.77 |
| CHEMBL65495 | — | — | 1 | 4.55 |
| CHEMBL62406 | — | — | 1 | 4.51 |
| CHEMBL164791 | — | — | 1 | 4.48 |
| CHEMBL303000 | — | — | 1 | 4.44 |
| CHEMBL304957 | — | — | 1 | 4.33 |
| CHEMBL67229 | — | — | 1 | 4.33 |
| CHEMBL63767 | — | — | 1 | 4.31 |
| CHEMBL293230 | — | — | 1 | 4.28 |
| CHEMBL294593 | — | — | 1 | 4.28 |
| CHEMBL63145 | — | — | 1 | 4.21 |
| CHEMBL63619 | — | — | 1 | 4.16 |
| CHEMBL294549 | — | — | 1 | 4.13 |
| CHEMBL302341 | — | — | 1 | 4.13 |
| CHEMBL67018 | — | — | 1 | 4.12 |
| CHEMBL441985 | — | — | 1 | 4.08 |
| CHEMBL306643 | — | — | 1 | 4.02 |
| CHEMBL444581 | — | — | 1 | 4.01 |
| CHEMBL292271 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433493 | — | IC50 | = | 74.13 | nM | 7.13 |
| CHEMBL63990 | — | IC50 | = | 676.08 | nM | 6.17 |
| CHEMBL278068 | — | IC50 | = | 1202.26 | nM | 5.92 |
| CHEMBL64937 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL67235 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL67369 | — | IC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL293669 | — | IC50 | = | 2398.83 | nM | 5.62 |
| CHEMBL164747 | — | IC50 | = | 2570.4 | nM | 5.59 |
| CHEMBL63907 | — | IC50 | = | 5623.41 | nM | 5.25 |
| CHEMBL65687 | — | IC50 | = | 12022.64 | nM | 4.92 |
| CHEMBL65523 | — | IC50 | = | 12022.64 | nM | 4.92 |
| CHEMBL433288 | — | IC50 | = | 16982.44 | nM | 4.77 |
| CHEMBL65495 | — | IC50 | = | 28183.83 | nM | 4.55 |
| CHEMBL62406 | — | IC50 | = | 30902.95 | nM | 4.51 |
| CHEMBL164791 | — | IC50 | = | 33113.11 | nM | 4.48 |
| CHEMBL303000 | — | IC50 | = | 36307.81 | nM | 4.44 |
| CHEMBL304957 | — | IC50 | = | 46773.51 | nM | 4.33 |
| CHEMBL67229 | — | IC50 | = | 46773.51 | nM | 4.33 |
| CHEMBL63767 | — | IC50 | = | 48977.88 | nM | 4.31 |
| CHEMBL293230 | — | IC50 | = | 52480.75 | nM | 4.28 |
| CHEMBL294593 | — | IC50 | = | 52480.75 | nM | 4.28 |
| CHEMBL63145 | — | IC50 | = | 61659.5 | nM | 4.21 |
| CHEMBL63619 | — | IC50 | = | 69183.1 | nM | 4.16 |
| CHEMBL294549 | — | IC50 | = | 74131.02 | nM | 4.13 |
| CHEMBL302341 | — | IC50 | = | 74131.02 | nM | 4.13 |
| CHEMBL67018 | — | IC50 | = | 75857.76 | nM | 4.12 |
| CHEMBL441985 | — | IC50 | = | 83176.38 | nM | 4.08 |
| CHEMBL306643 | — | IC50 | = | 95499.26 | nM | 4.02 |
| CHEMBL444581 | — | IC50 | = | 97723.72 | nM | 4.01 |
| CHEMBL65265 | — | IC50 | = | 147910.84 | nM | - |
| CHEMBL63667 | — | IC50 | = | 154881.66 | nM | - |
| CHEMBL63701 | — | IC50 | = | 114815.36 | nM | - |
| CHEMBL64938 | — | IC50 | = | 199526.23 | nM | - |
| CHEMBL65391 | — | IC50 | = | 501187.23 | nM | - |
| CHEMBL308667 | — | IC50 | = | 338844.16 | nM | - |
| CHEMBL65169 | — | IC50 | = | 338844.16 | nM | - |
| CHEMBL292989 | — | IC50 | = | 707945.78 | nM | - |
| CHEMBL67525 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL68008 | — | IC50 | = | 158489.32 | nM | - |
| CHEMBL64641 | — | IC50 | = | 575439.94 | nM | - |
| CHEMBL304123 | — | IC50 | = | 354813.39 | nM | - |
| CHEMBL68010 | — | IC50 | = | 204173.79 | nM | - |
| CHEMBL67213 | — | IC50 | = | 173780.08 | nM | - |
| CHEMBL63823 | — | IC50 | = | 354813.39 | nM | - |
| CHEMBL303962 | — | IC50 | = | 102329.3 | nM | - |
| CHEMBL448479 | — | IC50 | = | 147910.84 | nM | - |
| CHEMBL292271 | — | IC50 | = | 120226.44 | nM | - |