Assay Detail
Binding
CHEMBL671847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dopamine autoreceptor agonists as potential antipsychotics. 3.6-Propyl-4,5,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93428 | — | — | 1 | 5.00 |
| CHEMBL329444 | — | — | 1 | 5.00 |
| CHEMBL150550 | — | — | 2 | - |
| CHEMBL92784 | — | — | 1 | - |
| CHEMBL328548 | — | — | 1 | - |
| CHEMBL91453 | — | — | 1 | - |
| CHEMBL276500 | — | — | 1 | - |
| CHEMBL93972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93428 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL329444 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL150550 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL92784 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL150550 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL328548 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL91453 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL276500 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL93972 | — | IC50 | > | 10000.0 | nM | - |