Assay Detail
Binding
CHEMBL671909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and atypical antipsychotic profile of some 2-(2-piperidinoethyl)benzocycloalkanones as analogues of butyrophenone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.04 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.01 |
| CHEMBL87458 | — | — | 1 | 5.96 |
| CHEMBL87026 | — | — | 1 | 5.89 |
| CHEMBL87943 | — | — | 1 | 5.81 |
| CHEMBL87717 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 97.72 | nM | 7.01 |
| CHEMBL87458 | — | Ki | = | 1096.48 | nM | 5.96 |
| CHEMBL87026 | — | Ki | = | 1288.25 | nM | 5.89 |
| CHEMBL87943 | — | Ki | = | 1548.82 | nM | 5.81 |
| CHEMBL87717 | — | Ki | = | 2818.38 | nM | 5.55 |