Assay Detail
Binding
CHEMBL671910
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In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.88 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554199 | — | — | 1 | 6.90 |
| CHEMBL95112 | — | — | 1 | 6.49 |
| CHEMBL87026 | — | — | 1 | 5.89 |
| CHEMBL544091 | — | — | 1 | 5.86 |
| CHEMBL92145 | — | — | 1 | 5.83 |
| CHEMBL87943 | — | — | 1 | 5.81 |
| CHEMBL545727 | — | — | 1 | 5.81 |
| CHEMBL92673 | — | — | 1 | 5.60 |
| CHEMBL542181 | — | — | 1 | 5.43 |
| CHEMBL544089 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554199 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL95112 | — | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL87026 | — | Ki | = | 1288.25 | nM | 5.89 |
| CHEMBL544091 | — | Ki | = | 1380.38 | nM | 5.86 |
| CHEMBL92145 | — | Ki | = | 1479.11 | nM | 5.83 |
| CHEMBL87943 | — | Ki | = | 1548.82 | nM | 5.81 |
| CHEMBL545727 | — | Ki | = | 1548.82 | nM | 5.81 |
| CHEMBL92673 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL542181 | — | Ki | = | 3715.35 | nM | 5.43 |
| CHEMBL544089 | — | Ki | = | 7079.46 | nM | 5.15 |