Assay Detail
Binding
CHEMBL671944
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In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Aporphines as antagonists of dopamine D-1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.06 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 8.89 |
| CHEMBL119455 | — | — | 1 | 6.97 |
| CHEMBL155884 | — | — | 1 | 6.77 |
| CHEMBL155833 | — | — | 1 | 6.74 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.37 |
| CHEMBL153960 | — | — | 1 | 6.25 |
| CHEMBL345907 | — | — | 1 | 6.20 |
| CHEMBL157912 | (S)-BULBOCAPNINE | — | 1 | 6.13 |
| CHEMBL154989 | — | — | 1 | 6.09 |
| CHEMBL117841 | — | — | 1 | 5.49 |
| CHEMBL345822 | — | — | 1 | 5.48 |
| CHEMBL416288 | (S)APOMORPHINE | — | 1 | 5.44 |
| CHEMBL157879 | — | — | 1 | 5.30 |
| CHEMBL346017 | — | — | 1 | 5.07 |
| CHEMBL155246 | — | — | 1 | 4.92 |
| CHEMBL154709 | APOCIDEINE | — | 1 | 4.88 |
| CHEMBL157735 | — | — | 1 | - |
| CHEMBL155731 | QUINELORANE | 2.0 | 1 | - |
| CHEMBL155883 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL119455 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL155884 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL155833 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL53 | APOMORPHINE | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL153960 | — | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL345907 | — | IC50 | = | 637.0 | nM | 6.20 |
| CHEMBL157912 | (S)-BULBOCAPNINE | IC50 | = | 739.0 | nM | 6.13 |
| CHEMBL154989 | — | IC50 | = | 818.0 | nM | 6.09 |
| CHEMBL117841 | — | IC50 | = | 3276.0 | nM | 5.49 |
| CHEMBL345822 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL416288 | (S)APOMORPHINE | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL157879 | — | IC50 | = | 5061.0 | nM | 5.30 |
| CHEMBL346017 | — | IC50 | = | 8611.0 | nM | 5.07 |
| CHEMBL155246 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL154709 | APOCIDEINE | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL157735 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL155731 | QUINELORANE | IC50 | > | 10000.0 | nM | - |
| CHEMBL155883 | — | IC50 | > | 1000.0 | nM | - |