Assay Detail
Binding
CHEMBL671959
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Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.76 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.24 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 8.67 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 8.15 |
| CHEMBL113477 | — | — | 1 | 6.99 |
| CHEMBL111348 | — | — | 1 | 6.94 |
| CHEMBL68680 | — | — | 1 | 6.49 |
| CHEMBL321040 | — | — | 1 | 6.28 |
| CHEMBL418791 | — | — | 1 | 6.02 |
| CHEMBL320481 | — | — | 1 | 5.54 |
| CHEMBL113053 | — | — | 1 | 5.26 |
| CHEMBL326781 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 2.15 | nM | 8.67 |
| CHEMBL25856 | DIHYDREXIDINE | IC50 | = | 7.15 | nM | 8.15 |
| CHEMBL113477 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL111348 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL68680 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL321040 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL418791 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL320481 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL113053 | — | IC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL326781 | — | IC50 | = | 16700.0 | nM | 4.78 |