Assay Detail
Binding
CHEMBL672000
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Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.01 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 7.92 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.54 |
| CHEMBL318901 | — | — | 1 | 5.80 |
| CHEMBL95175 | — | — | 1 | 5.75 |
| CHEMBL97242 | — | — | 1 | 5.58 |
| CHEMBL317333 | — | — | 1 | 5.52 |
| CHEMBL327527 | — | — | 1 | 5.39 |
| CHEMBL313424 | — | — | 1 | 5.35 |
| CHEMBL97333 | — | — | 1 | 5.25 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | - |
| CHEMBL319352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12713 | SERTINDOLE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL318901 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL95175 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL97242 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL317333 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL327527 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL313424 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL97333 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL2 | PRAZOSIN | Ki | > | 5600.0 | nM | - |
| CHEMBL319352 | — | Ki | > | 100.0 | nM | - |