Assay Detail
Binding
CHEMBL672006
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Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.64 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119656 | — | — | 1 | 6.14 |
| CHEMBL25924 | — | — | 1 | 5.44 |
| CHEMBL333134 | — | — | 1 | 5.33 |
| CHEMBL115402 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119656 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL25924 | — | Ki | = | 3630.0 | nM | 5.44 |
| CHEMBL333134 | — | Ki | = | 4690.0 | nM | 5.33 |
| CHEMBL115402 | — | Ki | > | 10000.0 | nM | - |