Assay Detail
Binding
CHEMBL672007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.39 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91310 | — | — | 1 | 8.33 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.85 |
| CHEMBL432762 | — | — | 1 | 7.80 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.37 |
| CHEMBL90977 | — | — | 1 | 7.17 |
| CHEMBL328246 | — | — | 1 | 7.01 |
| CHEMBL88870 | — | — | 1 | 6.92 |
| CHEMBL73538 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91310 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL415300 | ISOCLOZAPINE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL432762 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL42 | CLOZAPINE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL90977 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL328246 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL88870 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL73538 | — | Ki | = | 200.0 | nM | 6.70 |