Assay Detail
Binding
CHEMBL672010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.30 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108463 | — | — | 1 | 5.30 |
| CHEMBL431367 | ROXINDOLE | 2.0 | 1 | - |
| CHEMBL109063 | — | — | 1 | - |
| CHEMBL109101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108463 | — | Ki | = | 5004.0 | nM | 5.30 |
| CHEMBL431367 | ROXINDOLE | Ki | > | 10000.0 | nM | - |
| CHEMBL109063 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL109101 | — | Ki | > | 10000.0 | nM | - |