Assay Detail
Binding
CHEMBL672016
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Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.68 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126590 | — | — | 1 | 6.11 |
| CHEMBL125916 | — | — | 1 | 6.01 |
| CHEMBL127317 | — | — | 1 | 5.87 |
| CHEMBL127344 | — | — | 1 | 5.84 |
| CHEMBL127400 | — | — | 1 | 5.83 |
| CHEMBL420510 | — | — | 1 | 5.80 |
| CHEMBL125193 | — | — | 1 | 5.78 |
| CHEMBL124444 | — | — | 1 | 5.59 |
| CHEMBL2112643 | — | — | 1 | 5.57 |
| CHEMBL25236 | BP-897 | — | 1 | 5.52 |
| CHEMBL435218 | — | — | 1 | 5.12 |
| CHEMBL340641 | — | — | 1 | 5.11 |
| CHEMBL123952 | — | — | 1 | - |
| CHEMBL339960 | — | — | 1 | - |
| CHEMBL126889 | — | — | 1 | - |
| CHEMBL341117 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126590 | — | Ki | = | 778.0 | nM | 6.11 |
| CHEMBL125916 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL127317 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL127344 | — | Ki | = | 1440.0 | nM | 5.84 |
| CHEMBL127400 | — | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL420510 | — | Ki | = | 1567.0 | nM | 5.80 |
| CHEMBL125193 | — | Ki | = | 1655.0 | nM | 5.78 |
| CHEMBL124444 | — | Ki | = | 2565.0 | nM | 5.59 |
| CHEMBL2112643 | — | Ki | = | 2676.0 | nM | 5.57 |
| CHEMBL25236 | BP-897 | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL435218 | — | Ki | = | 7664.0 | nM | 5.12 |
| CHEMBL340641 | — | Ki | = | 7750.0 | nM | 5.11 |
| CHEMBL123952 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL339960 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL126889 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL341117 | — | Ki | > | 10000.0 | nM | - |