Assay Detail
Binding
CHEMBL672092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(+/-)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepin, a new high-affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.50 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543398 | — | — | 1 | 9.05 |
| CHEMBL554009 | — | — | 1 | 8.92 |
| CHEMBL544114 | — | — | 1 | 8.30 |
| CHEMBL553503 | — | — | 1 | 8.15 |
| CHEMBL545000 | — | — | 1 | 8.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543398 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL554009 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL544114 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL553503 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL545000 | — | Ki | = | 8.8 | nM | 8.06 |