Assay Detail
Binding
CHEMBL672093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LTK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.40 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291143 | — | — | 1 | 8.52 |
| CHEMBL28338 | A-86929 | -1.0 | 1 | 8.05 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 7.85 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 7.23 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.00 |
| CHEMBL544814 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291143 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL28338 | A-86929 | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL25856 | DIHYDREXIDINE | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL24077 | (R)-SKF-38393 | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL59 | DOPAMINE | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL544814 | — | EC50 | = | 1700.0 | nM | 5.77 |