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Assay Detail

CHEMBL672094

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Functional
Potency in adenylate cyclase functional assay against Dopamine receptor D1
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(1A) dopamine receptor (CHEMBL2056)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists.
Gu YG, Bayburt EK, Michaelides MR, Lin CW, Shiosaki K.
Bioorg Med Chem Lett (1999) 9 : 1341 -1346
PubMed 10360732 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 7.34 8.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL281932 1 8.17
CHEMBL26965 1 8.07
CHEMBL285924 1 8.06
CHEMBL28338 A-86929 -1.0 1 8.05
CHEMBL25856 DIHYDREXIDINE 2.0 1 7.85
CHEMBL27101 1 7.75
CHEMBL27117 1 7.64
CHEMBL284644 1 7.42
CHEMBL287513 1 7.20
CHEMBL275379 1 6.96
CHEMBL284959 1 6.92
CHEMBL283247 1 6.75
CHEMBL282136 1 6.64
CHEMBL28054 1 6.50
CHEMBL26365 1 6.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL281932 EC50 = 6.7 nM 8.17
CHEMBL26965 EC50 = 8.6 nM 8.07
CHEMBL285924 EC50 = 8.8 nM 8.06
CHEMBL28338 A-86929 EC50 = 9.0 nM 8.05
CHEMBL25856 DIHYDREXIDINE EC50 = 14.0 nM 7.85
CHEMBL27101 EC50 = 18.0 nM 7.75
CHEMBL27117 EC50 = 23.0 nM 7.64
CHEMBL284644 EC50 = 38.0 nM 7.42
CHEMBL287513 EC50 = 63.0 nM 7.20
CHEMBL275379 EC50 = 110.0 nM 6.96
CHEMBL284959 EC50 = 120.0 nM 6.92
CHEMBL283247 EC50 = 180.0 nM 6.75
CHEMBL282136 EC50 = 230.0 nM 6.64
CHEMBL28054 EC50 = 320.0 nM 6.50
CHEMBL26365 EC50 = 800.0 nM 6.10