Assay Detail
Binding
CHEMBL672120
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Ability to displace [3H]WIN-35428 from dopamine transporter in rat caudate putamen tissue
71
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 71 | 6.84 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130477 | — | — | 1 | 9.00 |
| CHEMBL133786 | — | — | 1 | 9.00 |
| CHEMBL130255 | — | — | 1 | 8.82 |
| CHEMBL337510 | — | — | 1 | 8.77 |
| CHEMBL133795 | — | — | 1 | 8.70 |
| CHEMBL133043 | — | — | 1 | 8.60 |
| CHEMBL129899 | — | — | 1 | 8.60 |
| CHEMBL132198 | — | — | 1 | 8.59 |
| CHEMBL336654 | — | — | 1 | 8.49 |
| CHEMBL130668 | — | — | 1 | 8.47 |
| CHEMBL132241 | — | — | 1 | 8.37 |
| CHEMBL337052 | — | — | 1 | 8.24 |
| CHEMBL129885 | — | — | 1 | 8.23 |
| CHEMBL130394 | — | — | 1 | 8.20 |
| CHEMBL336413 | — | — | 1 | 8.19 |
| CHEMBL781 | MAZINDOL | 4.0 | 1 | 8.09 |
| CHEMBL335318 | — | — | 1 | 8.00 |
| CHEMBL133355 | — | — | 1 | 7.89 |
| CHEMBL132955 | — | — | 1 | 7.85 |
| CHEMBL133646 | — | — | 1 | 7.80 |
| CHEMBL335296 | — | — | 1 | 7.77 |
| CHEMBL132676 | — | — | 1 | 7.64 |
| CHEMBL132206 | — | — | 1 | 7.64 |
| CHEMBL334535 | — | — | 1 | 7.47 |
| CHEMBL334577 | — | — | 1 | 7.43 |
| CHEMBL340281 | — | — | 1 | 7.42 |
| CHEMBL134098 | — | — | 1 | 7.38 |
| CHEMBL337299 | — | — | 1 | 7.30 |
| CHEMBL339169 | — | — | 1 | 7.28 |
| CHEMBL442765 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133786 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL130477 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL130255 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL337510 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL133795 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL133043 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL129899 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL132198 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL336654 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL130668 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL132241 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL337052 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL129885 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL130394 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL336413 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL781 | MAZINDOL | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL335318 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL133355 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL132955 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL133646 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL335296 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL132676 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL132206 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL334535 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL334577 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL340281 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL134098 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL337299 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL339169 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL442765 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL336761 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL133902 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL338721 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL130198 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL336313 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL130372 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL339648 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL424640 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL134218 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL337468 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL133287 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL339841 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL131637 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL132630 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL336547 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL130747 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL340392 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL129962 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL337634 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL337004 | — | IC50 | = | 1600.0 | nM | 5.80 |