Assay Detail
Binding
CHEMBL672121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-dopamine uptake at dopamine transporter.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.51 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284394 | — | — | 1 | 9.00 |
| CHEMBL174532 | — | — | 1 | 7.85 |
| CHEMBL3143431 | — | — | 1 | 7.54 |
| CHEMBL176566 | — | — | 1 | 7.46 |
| CHEMBL369439 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284394 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL174532 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3143431 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL176566 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL369439 | — | IC50 | = | 2000.0 | nM | 5.70 |