Assay Detail
Binding
CHEMBL672156
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Tested for binding to dopamine receptor using [3H]apomorphine as radioligand in calf caudate nucleus homogenates.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Aporphines. 39. Synthesis, dopamine receptor binding, and pharmacological activity of (R)-(-)- and (S)-(+)-2-hydroxyapomorphine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.68 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 9.00 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.35 |
| CHEMBL19130 | — | — | 1 | 7.96 |
| CHEMBL54183 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL59 | DOPAMINE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL19130 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL54183 | — | IC50 | = | 4000.0 | nM | 5.40 |